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Index > Protein center > IL15(Gene name) > Human
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  • IL15 (Gene name),
  • Interleukin-15 (Protein name ),  IL15_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL15;
    Protein name:
    Interleukin-15(IL-15);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
    Subcellular Location:
    Isoform IL15-S21AA Cytoplasm Nucleus IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
    Protein Attributes:
    Sequence length:
    162
    Sequence:
    50:
    MRISKPHLRS | ISIQCYLCLL | LNSHFLTEAG | IHVFILGCFS | AGLPKTEANW | 
    100:
    VNVISDLKKI | EDLIQSMHID | ATLYTESDVH | PSCKVTAMKC | FLLELQVISL | 
    150:
    ESGDASIHDT | VENLIILANN | SLSSNGNVTE | SGCKECEELE | EKNIKEFLQS | 
    162:
    FVHIVQMFIN | TS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    UniGene:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-15
    Cat.:
    E0061h
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    96T
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    ELISA Kit for Human IL-15
    Cat.:
    E0061b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human IL-15
    Cat.:
    E0061m
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    Packing:
    96T
    ELISA Kit for Human IL-15
    Cat.:
    E0061p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human IL-15
    MSDS:
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    ELISA Kit for Human IL-15
    Cat.:
    E0061r
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    96T
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    CLIA Kit for Human IL-15
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    U0061r
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    Packing:
    96T
    Range:
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    CLIA Kit for Human IL-15
    MSDS:
    Please sign in first.
    CLIA Kit for Human IL-15
    Cat.:
    U0061b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-15
    Cat.:
    U0061m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-15
    Cat.:
    U0061h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human IL-15
    Cat.:
    U0061p
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human IL-15
    Cat.:
    P0061Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-15
    Cat.:
    P0061Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-15
    Cat.:
    P0061Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-15
    Polyclonal Antibody for Human IL-15
    Polyclonal Antibody for Human IL-15
    Monoclonal Antibody for Human IL-15
    Monoclonal Antibody for Human IL-15
    Monoclonal Antibody for Human IL-15
    Monoclonal Antibody for Human IL-15
    Monoclonal Antibody for Human IL-15
    Monoclonal Antibody for Human IL-15
    Protein for Human IL-15
    Protein for Human IL-15
    Protein for Human IL-15
    Protein for Human IL-15
    Protein for Human IL-15
    Protein for Human IL-15

    R&D Technical Data
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      12% SDS-PAGE Analysis

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    References
    1. 1.
      "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor."
      Grabstein K.H. , Eisenman J. , Shanebeck K. , Rauch C. , Srinivasan S. , Fung V. , Beers C. , Richardson J. , Schoenborn M.A. , Ahdieh M. , Johnson L. , Alderson M.R. , Watson J.D. , Anderson D.M. , Giri J.G.
      Science264:965-968(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S48AA)
      tissue: Bone marrow.
    2. 2.
      "Genomic sequence and chromosomal location of the human interleukin-15 gene (IL15)."
      Krause H. , Jandrig B. , Wernicke C. , Bulfone-Paus S. , Pohl T. , Diamantstein T.
      Cytokine8:667-674(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines."
      Meazza R. , Verdiani S. , Biassoni R. , Coppolecchia M. , Gaggero A. , Orengo A.M. , Colombo M.P. , Azzarone B. , Ferrini S.
      Oncogene12:2187-2192(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA)
      tissue: Lung cancer.
    4. 4.
      "Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides."
      Tagaya Y. , Kurys G. , Thies T.A. , Losi J.M. , Azimi N. , Hanover J.A. , Bamford R.N. , Waldmann T.A.
      Proc. Natl. Acad. Sci. U.S.A.94:14444-14449(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA)
      tissue: Testis.
    5. 5.
      "Expression of two IL-15 mRNA isoforms in human tumors does not correlate with secretion: role of different signal peptides."
      Meazza R. , Ferrini S.
      Submitted (1997-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      Li C.
      Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IL15-S21AA)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IL15-S21AA)
      tissue: Cerebellum.
      tissue: Heart.
    8. 8.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IL15-S21AA)
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IL15-S48AA AND IL15-S21AA)
      tissue: Colon.
    11. 11.
      "IL15 expression in human keratinocytes."
      Sorel M.A. , Jacques Y.
      Submitted (1994-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-162
      tissue: Epidermis.
    12. 12.
      "Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope."
      Lowe D.C. , Gerhardt S. , Ward A. , Hargreaves D. , Anderson M. , Ferraro F. , Pauptit R.A. , Pattison D.V. , Buchanan C. , Popovic B. , Finch D.K. , Wilkinson T. , Sleeman M. , Vaughan T.J. , Mallinder P.R.
      J. Mol. Biol.406:160-175(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 49-162 IN COMPLEX WITH ANTIBODY;DISULFIDE BONDS
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